DNA damage induced by auramine O in liver, kidney, and bone marrow of rats and mice, and in a human cell line (alkaline elution assay and SCE induction)
作者:
Silvio Parodi,
Leonardo Santi,
Patrizia Russo,
Adriana Albini,
Daniela Vecchio,
Mauro Pala,
Laura Ottaggio,
Antonino Carbone,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1982)
卷期:
Volume 9,
issue 5-6
页码: 941-952
ISSN:0098-4108
年代: 1982
DOI:10.1080/15287398209530216
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Auramine O has been reported to be carcinogenic in rats and mice. It has been reported as positive in some mutagenicity studies and negative in others. We have found that commercial auramine O is positive in inducing DNA damage in vivo in liver, kidney, and bone marrow cells. DNA damage was also induced after treatment in vitro of a human cell line. Commercial auramine O was also clearly positive for sister chromatid exchange (SCE) induction in vivo in bone marrow cells. Purified auramine was negative in terms of DNA damage and SCE induction. Our commercial auramine O had Michler's ketone as a major contaminant. This compound was capable of inducing both DNA fragmentation and an increase of SCE.
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