Indirect Catalytic Spectrophotometric Determination of Metamizol Following Oxidation by Lead Dioxide Immobilized in A Polyester Resin Bed
作者:
J.A. García Bautista,
L.Lahuerta Zamora,
J.V.García Mateo,
J.Martínez Calatayud,
期刊:
Analytical Letters
(Taylor Available online 1996)
卷期:
Volume 29,
issue 15
页码: 2667-2678
ISSN:0003-2719
年代: 1996
DOI:10.1080/00032719608002271
出版商: Taylor & Francis Group
关键词: Spectrophotometry;FIA;catalytic procedure;metamizol;solid-phase reactors
数据来源: Taylor
摘要:
A spectrophotometric-indirect procedure for the determination of metamizol is described. The method is based on the reaction of the drug in a solid-phase (lead dioxide immobilized in a polyester resin bed) in acidic media (perchloric acid 0.01 M as carrier). The lead dioxide reactor provides simultaneously an effective oxidation of the drug and a controlled liberation of Pb(II) which acts as catalyst on the reaction pyrogallol red-potassium persulphate; the oxidation of the red pyrogallol results in a less coloured solution. The decreased red colour (negative FIA peaks) is monitored at 520 nm. The calibration graph is linear in the interval 2–16 ppm in metamizol. The relative standard deviation for the determination of 10.4 ppm of metamizol is 2.9% (n=23) and the sample throughput is 72 h−1.
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