There are limited reconstructive options for segmental bone defects of the upper extremity larger than 6 cm in length, especially when associated with soft-tissue loss. Among the limited treatment options the osteoseptocutaneous fibular transplant is well established. The anatomy is reliable, the blood supply is constant, and the operative technique can be standardized. The advantage of including skin with the vascularized fibular transplant is twofold. First, the skin paddle can be used to augment the soft-tissue envelope. Second, the skin paddle serves as a monitor, providing an immediate, ongoing, and reliable method to monitor the blood flow to the graft. The osteoseptocutaneous fibular transplant proved to be an effective treatment of combined segmental bony and soft-tissue defects of the forearm and humerus.