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A high‐performance liquid chromatographic method for the determination of stobadin pharmacokinetics in serum

 

作者: Ladislav Šoltés,   Zoltán Kállay,   Štefan Bezek,   Viera Fedelesǒvá,  

 

期刊: Biopharmaceutics&Drug Disposition  （WILEY Available online 1991）
卷期: Volume 12, issue 1  

页码: 29-35

 

ISSN:0142-2782

 

年代: 1991

 

DOI:10.1002/bdd.2510120104

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Pharmacokinetics;Bioavailability;Stobadin;Gamma‐carboline;High‐performance liquid chromatography

 

数据来源: WILEY

 

摘要:

AbstractA high‐performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46·4 per cent in dog. In man peak serum concentrations ranged from 12 to 289ng ml−1after a single oral dose of stobadin dipalmitate (0·79 to 2·5mg

 

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