Prostaglandin‐D‐synthase (β‐trace protein) levels in rat cerebrospinal fluid
作者:
Kenji Kabeya,
Koichi Ishikawa,
Kenji Katakai,
Masatomo Watanabe,
Yoshihide Ohe,
Katsumi Wakabayashi,
Masatomo Mori,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 5
页码: 915-919
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cerebrospinal fluid;Development;Prostaglandin-D-synthase nb;β-Trace protein;Retinoic acid
数据来源: OVID
摘要:
THE precise role of prostaglandin-D-synthase β (trace protein), the major constituent of cerebrospinal fluid, is unclear. In the present study, a sensitive and highly specific fluoroimmunoassay was developed. The measurement of the enzyme levels in rat CSF revealed a developmental change in the CSF levels with the highest value of 6 6 ± 8μg/ml at 7 days after birth. No significant difference in the levels was seen between different times of day. Subcutaneous injections of all-transretinoic acid caused a dramatic decrease in the protein levels in a dose- and time-dependent manner. These findings may raise the possibility that prostaglandin-D-synthase in CSF is involved in retinoic acid action on the brain.
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