Diagnosis of visceral leishmaniasis in HIV‐infected individuals using peripheral blood smears
作者:
Pilar Martínez,
Elvira de la Vega,
Fernando Laguna,
Vicenç Soriano,
Sabino Puente,
Victoria Moreno,
Maria Sentchordi,
Carlos García-Aguado,
Juan González-Lahoz,
期刊:
AIDS
(OVID Available online 1993)
卷期:
Volume 7,
issue 2
页码: 227-230
ISSN:0269-9370
年代: 1993
出版商: OVID
关键词: HIV;Leishmania;kala-azar;AIDS diagnosis;Spain;opportunistic infections
数据来源: OVID
摘要:
ObjectiveTo compare the clinical and laboratory features of visceral leishmaniasis (kala-azar) in HIV-infected and non-infected subjects, and to determine the presence of Leishmania amastigotes in circulating leukocytes using peripheral blood smears.PatientsTwenty-eight HIV-infected and six HIV-negative adult patients diagnosed as having kala-azar presenting at one institution over a 7-year period.MethodsRetrospective review of clinical charts and re-examination of peripheral blood smears.ResultsThere were no significant differences in the clinical presentation and laboratory features of HIV-positive and HIV-negative patients. However, Leishmania amastigotes were observed in circulating leukocytes in eight out of the 17 available peripheral blood smears (15 from HIV-infected patients). All eight individuals presenting with Leishmania in peripheral blood leukocytes were HIV-positive.ConclusionsDirect visualization of Leishmania amastigotes in leukocytes on peripheral blood smears enabled the diagnosis of kala-azar in a high proportion [eight out of 15 (53%)] of our HIV-infected patients.
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