Melanoma Vaccines in DevelopmentLooking to the Future
作者:
Reinhard Dummer,
Frank O. Nestle,
期刊:
BioDrugs
(ADIS Available online 2000)
卷期:
Volume 13,
issue 4
页码: 227-231
ISSN:1173-8804
年代: 2000
出版商: ADIS
关键词: Malignant melanoma, treatment;Melanoma vaccine, therapeutic use;Melanoma vaccine gene therapy, therapeutic use;Research and development;Vaccine adjuvants;Vaccines, therapeutic use
数据来源: ADIS
摘要:
There is a body of evidence indicating that melanoma is an antigenic tumour. Since the efficacy of standard therapy in advanced stages of melanoma is rather poor, experimental immunotherapy aims to target this aggressive neoplasm. After the identification of several melanoma antigens, vaccination trials have been initiated in patients with metastatic disease using peptides, dendritic cells and gene therapy approaches including viral vectors or naked DNA. If the problems in inducing a constant and potent T cell response are solved, the stability of melanoma antigens and their presentation will decide whether these treatment approaches will reach significant relevance in daily clinical practice.
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