BackgroundHomeless adolescents are vulnerable to poor health outcomes owing to the dangerous and stressful environments in which they live. Despite their vulnerability, many of them are motivated to engage in self-care behaviors.ObjectiveThe specific aim of this study was to explore self-care attitudes and behaviors of homeless adolescents.MethodIndividual interviews were conducted with 15 homeless adolescents. Interviews were audiotaped, transcribed verbatim, and analyzed using the constant comparative method of grounded theory.ResultsFindings revealed a basic social process of taking care of oneself in a high-risk environment. This basic social process was supported by three categories: Becoming Aware of Oneself, Staying Alive With Limited Resources, and Handling One’s Own Health, each including two processes.DiscussionFindings support Orem’s conceptualizations of self-care and self-care agency and suggest the need for programs to support further healthy growth and development among homeless adolescents.