Synthesis and Hydrolysis of Polymers Having Anesthetic or Amantadine Residues in Sidechains
作者:
Kazuo Sugiyama,
期刊:
Journal of Macromolecular Science: Part A - Chemistry
(Taylor Available online 1986)
卷期:
Volume 23,
issue 10
页码: 1155-1164
ISSN:0022-233X
年代: 1986
DOI:10.1080/00222338608069485
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The polymerizable derivatives of chemotherapeutic agents such as benzocaine, procaine, and amantadine were prepared and free-radical copolymerized with styrene or methyl methacrylate in order to obtain polymers with pharmacological activity and increased duration of action of the drugs. The monomeric and polymeric derivatives were subjected to hydrolysis in vitro in order to measure the release of the active ingredient.
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