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ENANTIOSEPARATION ON AMYLOSE TRIS(3,5-DIMETHOXYPHENYL CARBAMATE): APPLICATION TO COMMERCIAL PHARMACEUTICAL CHIRAL DRUGS

 

作者: QueziaB. Cass,   M.Elizabeth Tiritan,   SilvanaA. Calafatti,   StephenA. Matlin,  

 

期刊: Journal of Liquid Chromatography & Related Technologies  （Taylor Available online 1999）
卷期: Volume 22, issue 20  

页码: 3091-3099

 

ISSN:1082-6076

 

年代: 1999

 

DOI:10.1081/JLC-100102077

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

The enantioselectivity of the amylose tris(3,5-dimethoxyphenyl carbamate) phase towards some β-blockers was investigated. A sensitive HPLC method was developed for the enantiomers of metoprolol and betaxolol. The validated methods were suitable for the analysis of enantiomeric composition in a variety of pharmaceutical formulations of both drugs.

 

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