The muscular coat of human small intestine is constituted by a ‘special’ layer, by the main component of the circular layer, by the region between the circular and the longitudinal layers and by the longitudinal layer. The ‘special’ layer is made up of the innermost 4–6 rows of muscle cells of the circular layer and is separated from the main component of the circular layer by a space in which an abundant connective tissue and numerous nerve fibers rich in nerve endings are located. Cells identified as interstitial cells of Cajal are located inside the ‘special’ layer, the space between it and the main component of the circular layer and in the region between the circular and the longitudinal layers. In this region small bundles of obliquely orientated muscle cells, apparently bridging the circular to the longitudinal lay