Scaling toxicity from laboratory animals to people: An example with nitrogen dioxide
作者:
StevenA. Book,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1982)
卷期:
Volume 9,
issue 5-6
页码: 719-725
ISSN:0098-4108
年代: 1982
DOI:10.1080/15287398209530199
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Published data on the toxicity of nitrogen dioxide (as a model compound) from five laboratory animal species were utilized to scale the relationship of dose and toxic effect to the human species. A minute volume of inspired air was used as a metabolic scaling factor, predicting a median lethality during the time of exposure of 174 ppm NO2for a 1‐h exposure for people. This work demonstrates a method of predicting effects in people when only data for laboratory animals exist. It also shows the value of planning toxicology studies that utilize several animal species, so that their data may be applied to forecasting the human condition.
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