Synthesis of 3-Deoxy-3-C-Trifluoromethyl-d-Ribose Fromd-Xylose ord-Glucose
作者:
S. Lavaire,
R. Plantier-Royon,
C. Portella,
期刊:
Journal of Carbohydrate Chemistry
(Taylor Available online 1996)
卷期:
Volume 15,
issue 3
页码: 361-370
ISSN:0732-8303
年代: 1996
DOI:10.1080/07328309608005659
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The synthesis of 3-deoxy-1,2,O-isopropylidene-3-C-trifluoromethyl-α-D-ribofuranose is described. After a first approach from a commercial D-xylose derivative which was limited by an incomplete stereoselectivity, the synthesis of the title compound was performed from 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose by a reaction sequence where key steps: trifluoromethylation with CF3SiMe3and radical deoxygenation are highly stereoselective.
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