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Synergism of chronic alcoholism and hepatitis B infection in liver disease

 

作者: HAU‐TIM CHUNG,   CHING‐LUNG LAI,   PUI‐CHEE WU,   ANNA S. F. LOK,  

 

期刊: Journal of Gastroenterology and Hepatology  (WILEY Available online 1989)
卷期: Volume 4, issue 1  

页码: 11-16

 

ISSN:0815-9319

 

年代: 1989

 

DOI:10.1111/j.1440-1746.1989.tb00801.x

 

出版商: Blackwell Publishing Ltd

 

关键词: alcoholic liver disease;hepatitis B infection;synergism.

 

数据来源: WILEY

 

摘要:

AbstratOne hundred and fifty‐seven patients with alcoholic liver disease were studied. Hepatitis B surface antigen (HBsAg) was positive in 20.4% of the patients. Those who were positive for the HBsAg presented at an earlier age, had a lower albumin level, a higher globulin level, a more prolonged prothrombin time, were more likely to have features of cirrhosis in the liver biopsy, and were probably more likely to suffer from hepatic encephalopathy in the follow‐up compared with those negative for HBsAg. The mortality of subjects was low both on admission and during follow‐up. It is concluded that chronic alcoholism and hepatitis B virus infection act synergistically in producing more severe liver damage and causing cirrhosis at a younger age compared with chronic alcoholism alone. One possible reason for the low mortality of the patients might have been their relatively good nutritional s

 

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