Growth factor gene expression in tubular epithelial injury
作者:
Marc Hammerman,
Steven Miller,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 1995)
卷期:
Volume 4,
issue 3
页码: 258-262
ISSN:1062-4821
年代: 1995
出版商: OVID
数据来源: OVID
摘要:
In animal models of acute renal injury, administration of epidermal, insulin-like or hepatocyte growth factor accelerates restoration of kidney function and normalization of histology, and reduces mortality. Mechanisms for such action include stimulation of anabolism, maintenance of glomerular filtration, and enhancement of tubular regeneration. Further studies are needed to establish the utility of growth factors as therapeutic agents for acute renal failure in humans.
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