首页   按字顺浏览 期刊浏览 卷期浏览 Neuro-Ototoxicity in Andean Adults With Chronic Lead and Noise Exposure
Neuro-Ototoxicity in Andean Adults With Chronic Lead and Noise Exposure

 

作者: S. Counter,   Leo Buchanan,  

 

期刊: Journal of Occupational and Environmental Medicine  (OVID Available online 2002)
卷期: Volume 44, issue 1  

页码: 30-38

 

ISSN:1076-2752

 

年代: 2002

 

出版商: OVID

 

数据来源: OVID

 

摘要:

Brainstem auditory evoked responses and audiological thresholds were used as biomarkers for neuro-ototoxicity in adults with chronic lead (Pb) intoxication from long-term Pb exposure in ceramic-glazing work. Venous blood samples collected from 30 adults (15 men and 15 women) indicated a mean blood Pb level of 45.1 &mgr;g/dL (SD, 19.5; range, 11.2 to 80.0 &mgr;g/dL) and in excess of the World Health Organization health-based biological limits (men, 46.2 &mgr;g/dL; SD, 19.6; range, 18.3 to 80.0 &mgr;g/dL; women, 44.0 &mgr;g/dL; SD, 20.1; range,11.2 to 74.2 &mgr;g/dL). Mean auditory thresholds at frequencies susceptible to ototoxicity (2.0, 3.0, 4.0, 6.0, and 8.0 kHz) revealed sensory-neural hearing loss in men, which may be attributable to occupational noise exposure in combination with Pb intoxication. Bilateral brainstem auditory evoked response tests on participants with elevated blood Pb levels (mean, 47.0 &mgr;g/dL) showed delayed wave latencies consistent with sensory-neural hearing impairment. The results suggest that environmental noise exposure must be considered an important factor in determining sensory-neural hearing status in occupationally Pb-exposed adults.

 

点击下载:  PDF (199KB)



返 回