Maturation of the Pituitary-Adrenal Function in Rat Fetuses
作者:
Françoise Boudouresque,
Viviane Guillaume,
Michel Grino,
Vladimir Strbak,
Thierry Chautard,
Bernad Conte-Devolx,
Charles Oliver,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 48,
issue 4
页码: 417-422
ISSN:0028-3835
年代: 1988
DOI:10.1159/000125043
出版商: S. Karger AG
关键词: Corticosterone;Rat fetuses;Passive immunization;Corticotropin-releasing factor;Adrenocorticotropic hormone
数据来源: Karger
摘要:
Plasma adrenocorticotropic hormone (ACTH) and corticosterone were detectable in fetal plasma on day 16 of pregnancy. Thereafter, the levels of both hormones increased steadily in a parallel manner and reached a peak on day 19 of pregnancy. Administration of an antiserum anti-rat corticotropin-releasing factor (CRF) to pregnant rats was followed by a significant decrease in fetal plasma corticosterone as early as day 17. Plasma ACTH measured under the same experimental conditions on day 19 of gestation was also significantly decreased. Similar results have been obtained with fetal plasma collected from adrenalectomized pregnant rats, indicating that the plasma corticosterone decrease in fetuses after immunoneutralization of CRF reflects changes in fetal adrenal secretion and not a diminution of corticosterone transfer from the maternal to the fetal circulation. These results show that endogenous CRF begins to play a physiological role in the regulation of ACTH and corticosterone secretion as early as in 17-day-old fetuses. This effect may occur before the connections between the neurosecretory CRF axons and the hypophysial portal capillaries have been established. Therefore, endogenous CRF may enter the hypophysial portal circulation after intercellular diffusion in hypothalamic tissue.
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