Abnormalities in ureter and kidney development in mice given acetazolamide‐amiloride or dimethadione (DMO) during embryogenesis
作者:
Thomas A. Miller,
William J. Scott,
期刊:
Teratology
(WILEY Available online 1992)
卷期:
Volume 46,
issue 6
页码: 541-550
ISSN:0040-3709
年代: 1992
DOI:10.1002/tera.1420460603
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThese experiments more accurately define the effects of the combination acetazolamide‐amiloride or a single dose of dimethadione (DMO), the active metabolite of trimethadione, on the development of the ureter. When acetazolamide‐amiloride was administered in C57BL/6NCrlBR mice on day 9, 9.5, or 10 of gestation (plug = day 0) a second ureter was formed, anterior to the original ureter, inducing a second kidney. The second ureter then fails to make a connection with the developing bladder and remains attached to the mesonephric duct. The mesonephric duct becomes the vas deferens in the male and deteriorates completely in the female leading to either a resticted ureter or a blocked ureter depending on the sex of the fetus. Administration of a single dose of DMO between gestational day 9 and 10.3 produced both renal agenesis and ureters of varying lengths. Some ureters were of normal length with a tuft of one or two nephrons at their tip, while others were one half or one quarter of their normal length. In some instances the ureter was completely absent. The reason for this strong effect on the ureter is unknown. © 1992 Wiley‐Lis
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