Comparative metabolism of aspartame in experimental animals and humans
作者:
R. E. Ranney,
J. A. Oppermann,
E. Muldoon,
F. G. McMahon,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1976)
卷期:
Volume 2,
issue 2
页码: 441-451
ISSN:0098-4108
年代: 1976
DOI:10.1080/15287397609529445
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Aspartame [SC‐18862; 3‐amino‐H‐(α‐carboxyphenethyl)succinamic acid, methyl ester, the methyl ester of aspartylphenylalanine] is a sweetening agent that organoleptically has about 180 times the sweetness of sugar. The metabolism of aspartame has been studied in mice, rats, rabbits, dogs, monkeys, and humans. The compound was digested in all species in the same way as are natural constituents of the diet. Hydrolysis of the methyl group by intestinal esterases yielded methanol, which was oxidized in the one‐carbon metabolic pool to CO2. The resultant dipeptide was split at the mucosal surface by dipeptidases and the free amino acids were absorbed. The aspartic acid moiety was transformed in large part to CO2through its entry into the tricarboxylic acid cycle. Phenylalanine was primarily incorporated into body protein either unchanged or as its major metabolite, tyrosine.
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