Gradionation: Hypothesis for Positioning and Patterning*
作者:
L. E. ROTH,
D. J. PIHLAJA,
期刊:
The Journal of Protozoology
(WILEY Available online 1977)
卷期:
Volume 24,
issue 1
页码: 2-9
ISSN:0022-3921
年代: 1977
DOI:10.1111/j.1550-7408.1977.tb05273.x
出版商: Blackwell Publishing Ltd
关键词: Gradionation;patterning;rosettes;membranes;microtubules;allosterism;cooperativity
数据来源: WILEY
摘要:
SYNOPSIS.The interaction of contiguous proteins is explored in microtubules, rosettes, and membranes based on the well established molecular phenomena of cooperativity and allosterism. It is proposed that conformational gradients in protein arrays cause the formation of gradions by nearest‐neighbor interactions. Gradions are repeating functional molecular sequences that contain several conformational forms of one or more proteins, with the result that different reactive sites can exist in the same molecular architecture at any one time. Gradionators are small controlling molecules that may be microscopically visible as layers or linkages, but could also be smaller. Some of the presently available supporting evidence and its functional implications are discussed, including the possibility that theraison d'etrefor membrane‐particle arrays is to enhance the regulation and amplification capabilities of cell syst
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