Pustular Psoriasis and Aseptic Purulent Arthritis: Possible Role of Leukotrienes B4and C4in a Flare of Synovitis
作者:
S. Kawana,
S. Nishiyama,
期刊:
Dermatology
(Karger Available online 1995)
卷期:
Volume 190,
issue 1
页码: 35-38
ISSN:1018-8665
年代: 1995
DOI:10.1159/000246631
出版商: S. Karger AG
关键词: Pustular psoriasis;Arthritis;Polymorphonuclear leukocyte;Myocardial infarction;Leukotrienes B4and C4
数据来源: Karger
摘要:
Background: Arthritis is a frequent complication of pustular psoriasis. However, the mechanism of onset of this arthritis still remains unclear. Objectives: The present study was conducted to determine whether leukotriene (LT) B4 or LTC4 is one of the pro inflammatory mediators that possibly enhance exacerbation of the arthritis lesions. Methods: We investigated the condition of the arthritis and autopsy findings of two cases of generalized pustular psoriasis with the severe complication of aseptic purulent arthritis. We also measured the synovial fluid levels of LTB4 and LTC4 by radioimmunoassay. Results: The collected synovial fluid was purulent, but nonbacterial, and the synovium of the knee joint showed histopathologic evidence of polymorphonuclear leukocyte (PMN) invasion, edema and dilatation of small vessels showing similarity to a histologic reaction in the skin lesions. The immunoreactive (i-) LTB4 and i-LTC4 in the samples significantly exceeded the amount measured in osteoarthritis patients used as the controls. Conclusion: Thus, i-LTB4 and i-LTC4 appear to be generated in the arthritis lesions of pustular psoriasis, the former attracting PMNs to the joints and the latter causing exudation of synovial fluid.
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