Sarcoidosis Patients Have Bronchial Hyperreactivity and Signs of Mast Cell Activation in Their Bronchoalveolar Lavage
作者:
Mary Berlin Öhrn,
C. Magnus Sköld,
Marianne van Hage-Hamsten,
Olöf Sigurdardottir,
Olle Zetterström,
Anders Eklund,
期刊:
Respiration
(Karger Available online 1995)
卷期:
Volume 62,
issue 3
页码: 136-142
ISSN:0025-7931
年代: 1995
DOI:10.1159/000196408
出版商: S. Karger AG
关键词: Albumin;Bronchial hyperreactivity;Fibronectin;Hyaluronan;Mast cells;Sarcoidosis;Tryptase;Vitronectin
数据来源: Karger
摘要:
An increased (p < 0.001) frequency of bronchial hyperreactivity (BHR) was found in sarcoidosis patients as compared with healthy volunteers. The patients had more mast cells (p < 0.001) and tryptase (p < 0.001) in their bronchoalveolar lavage fluid, but there were no differences between BHR-positive and BHR-negative patients. Furthermore, the bronchoalveolar lavage fluid concentrations of macrophages, lymphocytes, and of the soluble components albumin, fibronectin, and vitronectin were also elevated in the sarcoidosis patients, indicating an ongoing inflammation in the airways and/or in the interstitium. We observed no significant differences in the parameters when the sarcoidosis patients were subdivided into BHR, clinical activity, or chest X-ray stages. Our findings may indicate a multifactorial background to the hyperreactivity.
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