The Role of Epidermal Proliferation in the Pathogenesis of Psoriasis
作者:
P.C.M. van de Kerkhof,
P.E.J. van Erp,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1996)
卷期:
Volume 9,
issue 6
页码: 343-354
ISSN:1660-5527
年代: 1996
DOI:10.1159/000211445
出版商: S. Karger AG
关键词: Epidermis;Keratinization;Psoriasis
数据来源: Karger
摘要:
The micromorphological appearance of the psoriatic lesion is characterized by cutaneous inflammation, epidermal acanthosis and abnormal keratinization. The relevance of immunological factors has been reviewed in recent literature. Despite a longstanding interest of many centres in the pathogenesis of psoriasis, the position of epidermal proliferation, a key feature of the psoriatic plaque, remains to be established. The aim of the present review was to provide evidence from the literature and from our own work that enables us to answer the question to what extent epidermal proliferation might be a primary pathogenetic event or whether it represents a secondary phenomenon resulting from other abnormalities.
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