Turnover and Urinary Excretion of Free and Acetylated M.S. 222 by Rainbow Trout,Salmo gairdneri
作者:
Joseph B. Hunn,
Richard A. Schoettger,
Wayne A. Willford,
期刊:
Journal of the Fisheries Board of Canada
(NRC Available online 1968)
卷期:
Volume 25,
issue 1
页码: 25-31
ISSN:0706-652X
年代: 1968
DOI:10.1139/f68-003
出版商: NRC Research Press
数据来源: NRC
摘要:
Rainbow trout: (Salmo gairdneri) anesthetized in 100 mg/liter of M.S. 222 at 12 C excreted the drug in free and acetylated forms via the urine during a 24-hr recovery period in freshwater. Of the M.S. 222 excreted, 77–96% was acetylated. Blood levels of free drug in anesthetized trout approximated 75% of the anesthetic concentration, but the amount of acetylated M.S. 222 was relatively insignificant. The blood and urine were cleared of the two fractions of M.S. 222 in 8 and 24 hr respectively. Low levels of aromatic amines of natural origin occurred in blood and urine and were subtracted from measurements of M.S. 222. Intraperitoneal injections of 10–100 mg/kg of M.S. 222 did not induce anesthesia; however, the 24-hr pattern of drug excretion was similar to that observed after anesthesia by immersion. Only 15–21% of the injected dose was found in the urine, suggesting a second route of drug elimination.
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