Cushing's Syndrome Due to Ectopic ACTH Production by a Nasal Paraganglioma
作者:
DARRELL APPLE,
KENNETH KREINES,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1982)
卷期:
Volume 283,
issue 1
页码: 32-35
ISSN:0002-9629
年代: 1982
出版商: OVID
关键词: Cushing's syndrome ACTH production;Paraganglioma Paranasal sinuses
数据来源: OVID
摘要:
A patient is described with Cushingoid features and a tumor of the paranasal sinuses. Laboratory studies revealed hyperglycemia, hypokalemia, alkalosis, hypercortisolemia, and elevated serum ACTH levels. The cortisol level increased briskly in response to parenteral ACTH, but was only partially suppressed by dexamethasone. Microscopically, the tumor was found to be a paraganglioma containing many neurosecretory granules. Treatment with metyrapone, o, p'-DDD, and irradiation of the tumor resulted in a lasting remission. It is concluded that this unique patient suffered from Cushing's syndrome due to ectopic ACTH production by a paraganglioma of the paranasal sinuses.
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