Thioredoxin reductase and cancer cell growth inhibition by organotellurium antioxidants
作者:
Lars Engman,
Nawaf Al-Maharik,
Michael McNaughton,
Anne Birmingham,
Garth Powis,
期刊:
Anti-Cancer Drugs
(OVID Available online 2003)
卷期:
Volume 14,
issue 2
页码: 153-161
ISSN:0959-4973
年代: 2003
出版商: OVID
关键词: antioxidant;antitumor activity;organotellurium compound;thioredoxin reductase
数据来源: OVID
摘要:
Thioredoxin (Trx) expression is increased in several human primary cancers and the Trx/Trx reductase (TrxR) system therefore provides an attractive target for cancer drug development. Novel organotellurium antioxidants, especially a primitive analog of vitamin E (compound 1d) and compounds 7, 9 and 10—all carrying highly functionalized 4-(dialkylamino)phenyltelluro groups to secure high antioxidative capacity—were found to inhibit TrxR with IC50values in the low micromolar range. Whereas antioxidant 1d also inhibited the growth of MCF-7 human breast cancer cells in culture at a similar level (IC50=1.8 μM), the other TrxR inhibitors were inactive in concentrations below about 10 μM.
点击下载:
PDF
(140KB)
返 回