Recombinant enkephalinase effectively inhibits substance P-induced miosis in the rabbit eye cup model
作者:
AndersonJanet A.,
HernandezEdward,
DuzmanEfraim,
MalfroyBernard,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 6
页码: 543-547
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999594
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Enkephalinase (EC 3.4.24.11) is a naturally occurring, membrane-bound peptidase that degrades substance Pin vivoandin vitro.Addition of this neutral endopeptidase to a rabbit eye cup model partially inhibits substance P-induced contraction of the iris sphincter muscle. Inactivation of substance P is reversed by thiorphan, a specific inhibitor of enkephalinase. These results show that enkephalinase degradation of substance P produces metabolites that are physiologically inactive in iris contraction. We also observed that atropine acts synergistically with enkephalinase to completely abolish substance P-induced iris contraction suggesting that the action of substance P on the iris contains an acetylcholine-stimulatory effect which is not lost by enkephalinase treatment.
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