Canine Pulmonary Hypertension Model Induced by Pulmonary Artery Embolization of Gelatin Sponges
作者:
Satoshi Yamamoto,
Katsunobu Kawahara,
Takao Takahashi,
Tsutomu Tagawa,
Akihiro Nakamura,
Masashi Muraoka,
Masao Tomita,
期刊:
Respiration
(Karger Available online 1995)
卷期:
Volume 62,
issue 5
页码: 244-247
ISSN:0025-7931
年代: 1995
DOI:10.1159/000196456
出版商: S. Karger AG
关键词: Pulmonary hypertension;Pulmonary artery embolization;Gelatin sponge;Dog;Echocardiography
数据来源: Karger
摘要:
We attempted to develop a pulmonary hypertension model in dogs by gelatin sponge embolization. We then monitored right-ventricular pressure overload by echocardiography. Gelatin sponges (Spongel®, Yamanouchi, Tokyo) were homogenized and mixed in normal saline (0.6 mg/ml). The mixture was administered via the jugular vein to general pulmonary emboli. Repeated administration of the sponges increased the mean pulmonary arterial pressure and caused right ventricular pressure overload. The degree of pulmonary hypertension was proportional to the volume of gelatin sponge injected. Echocardiography, performed both before and after embolization, proved useful assessing for the degree of right-ventricular pressure overload
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