Chapter 8: Perspectives for the use of biological indicators for the assessment of radiation induced responses and impairments: Are there ‘common denominators’ in different radiation exposure scenarios as a target for predictive assessment? reflections on a panel discussion under the chairmanship ofT. M. Fliedner
作者:
Dirk Densow,
期刊:
STEM CELLS
(WILEY Available online 1995)
卷期:
Volume 13,
issue S1
页码: 307-317
ISSN:1066-5099
年代: 1995
DOI:10.1002/stem.5530130738
出版商: John Wiley&Sons, Ltd.
关键词: Radiation accidents;Radiation‐induced late effects;Biological indicators;Acute radiation syndrome;Ionizing radiation;Total body irradiation;Internal contamination
数据来源: WILEY
摘要:
AbstractThe first panel discussion of the International Searle‐Foundation Workshop on Biological Indicators of Exposure to Ionizing Radiation was directed at identifying ‘common denominators’ for the development of somatic late effects. The presented accidents were analyzed in terms of occurrence of total body or partial body irradiation, external or internal contamination, onset of early signs or symptoms of acute radiation syndrome, reduction of life expectancy, and occurrence of neoplastic or non‐neoplastic disorders. Evidence of radiation effects was sought in the victims' cell systems and in any cellular or molecular response to ionizing radiation, and whether other complicating factors could be established. From the results presented during the meeting, as well as from a review of the relevant literature, it is, however, rather unlikely that a single parameter will emerge by which the late effects of ionizing radiation in man can be determined easily. Instead, a couple of acute and chronic effects of exposure to ionizing radiation could be identified which are more or less common to any given exposure s
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