CD117 (KIT): A Diverse Protein With Selective Applications in Surgical Pathology
作者:
Pamela Gibson,
Kumarasen Cooper,
期刊:
Advances in Anatomic Pathology
(OVID Available online 2002)
卷期:
Volume 9,
issue 1
页码: 65-69
ISSN:1072-4109
年代: 2002
出版商: OVID
关键词: CD117;c-kit;Gastrointestinal stromal tumor;Immunohistochemistry
数据来源: OVID
摘要:
CD 117 (KIT) is a transmembrane, tyrosine kinase growth factor receptor which is expressed on numerous diverse fetal and adult cells including hematopoietic cells, mast cells, melanocytes, germ cells, and the interstitial cells of Cajal. Its expression in tumors is also diverse, but with selective use and attention to specific staining patterns, this marker is useful in the identification of gastrointestinal stromal tumors, mast cell tumors, and seminomatous germ cell tumors.
点击下载:
PDF
(53KB)
返 回