Physical Dependence on Clonazepam in Dogs
作者:
Rudolf Scherkl,
Hans-Hasso Frey,
期刊:
Pharmacology
(Karger Available online 1986)
卷期:
Volume 32,
issue 1
页码: 18-24
ISSN:0031-7012
年代: 1986
DOI:10.1159/000138148
出版商: S. Karger AG
关键词: Clonazepam;Flumazepil;Physical dependence
数据来源: Karger
摘要:
Six dogs were, under constant environmental conditions, treated for 7 weeks with clonazepam (0.5 mg/kg b.i.d. orally). Already after 1 week of treatment, slight symptoms of withdrawal could be elicited by intravenous injection of flumazepil (Ro 15-1788). When clonazepam was finally withdrawn, a self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss. The syndrome was most pronounced on days 2 and 3 after withdrawal, after 1 week all signs of physical dependence had disappeared.
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