Effect of Steroids on Vasoactive Intestinal Peptide in Discrete Brain Regions and Peripheral Tissues
作者:
W.H. Rotsztejn,
J. Besson,
B. Briaud,
L. Gagnant,
G. Rosselin,
C. Kordon,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 31,
issue 4
页码: 287-291
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123090
出版商: S. Karger AG
关键词: Castration;Adrenalectomy;Corticosteroids;VIP
数据来源: Karger
摘要:
The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increases them in the adenohypophysis, two structures known to contain large amounts of glucocorticoid receptors. Corticosterone administration restores VIP levels to control values only in the dorsal hippocampus. In contrast, dexamethasone counteracts both the decrease and the increase of VIP concentrations obtained after ADX in the hippocampus and in the adenohypophysis respectively. The present results suggest that corticosteroids can be involved in the regulation of VIP actions both in the brain and in the adenohypophysis.
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