Immune Complex Specific for the Pancreatic Duct Antigen in Patients with Idiopathic Chronic Pancreatitis and Sjögren Syndrome
作者:
OnoderaMachi,
OkazakiKazuichi,
MoritaMasanori,
NishimoriIsao,
YamamotoYasutake,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 19,
issue 1
页码: 23-29
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409008005
出版商: Taylor&Francis
关键词: idiopathic chronic pancreatitis;Sjögren syndrome;immune complex;autoantibodies
数据来源: Taylor
摘要:
Circulating immune complexes (ICs) containing the pancreatic antigen against SP3–1 monoclonal antibody were measured in patients with idiopathic chronic pancreatitis (ICP) and Sjögren syndrome (SjS) by Raji cell and solid-phase radioimmuno-assays (RIA). The mean serum levels of ICs measured by solid-phase RIA were significantly higher in patients with ICP (n = 23) and SjS (n = 21) than control (n = 15, p<0.05, p<0.02, respectively). ICs were positive in 10 patients with ICP (43%) and 12 SjS patients (57%). Raji cell assay also revealed a significantly higher serum ICs levels in patients with ICP (n = 17) and SjS (n = 12) compared with those of control (n = 7, p<0.025, p<0.005, respectively). Seven patients with ICP (41%) and 8 SjS patients (67%) had positive ICs. This was in contrast to the normal level of ICs in patients with alcoholic chronic pancreatitis, primary biliary cirrhosis, and chronic thyroiditis. Our analysis demonstrated a significant and positive relationship between RIA and Raji cell assay (r = 0.70, p<0.05). Our results suggest that ICs specific for SP3–1 may play a role in the pathophysiology of ICP and SjS.
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