Vascular Prostacyclin and Plasminogen Activator Activity in Experimental and Clinical Conditions of Disturbed Haemostasis or Thrombosis
作者:
G. de Gaetano,
G. Remuzzi,
M. Mysliwiec,
M.B. Donati,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1979)
卷期:
Volume 8,
issue 3-5
页码: 300-311
ISSN:1424-8832
年代: 1979
DOI:10.1159/000214320
出版商: S. Karger AG
关键词: Prostacyclin;Plasminogen activator;Haemostasis;Thrombosis
数据来源: Karger
摘要:
In several experimental and clinical conditions associated with thrombotic tendency, or complicated by thrombotic episodes, either prostacyclin (which inhibits platelet aggregation) or plasminogen activator (which promotes fibrinolysis), or both, appear to be decreased in the vessel wall. In other conditions, however, either activity may not change or even be increased. Possibly, vascular damage is followed by an early stimulation of both activities (a defence mechanism?) which may be subsequently reduced or exhausted. While the role of vascular plasminogen activator in haemorrhagic conditions is apparently unknown, prostacyclin activity appears to be markedly enhanced both in experimental animals and in patients with uraemia and bleeding complications. There is a suggestive evidence that uraemic plasma powerfully stimulates vascular prostacyclin generation.
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