In Vitro and in Vivo Evaluation of Two Factor VIII Concentrates Virally Inactivated by Solvent-Detergent or by Pasteurization
作者:
PeerlinckK.,
AmoutJ.,
TamiseM.,
VanherleA.,
FonduP.,
VennylenJ.,
期刊:
Acta Clinica Belgica
(Taylor Available online 1991)
卷期:
Volume 46,
issue 5
页码: 298-304
ISSN:1784-3286
年代: 1991
DOI:10.1080/17843286.1991.11718180
出版商: Taylor&Francis
数据来源: Taylor
摘要:
SummaryThe present study compares two new factor VIII preparations currently used in the treatment of haemophilia A. Factor VIII was partially purified from plasma obtained from unpaid voluntary Belgian donors in the blood transfusion centers of Lille and Amsterdam and virus-inactivated by exposure to solvent-detergent (FVI1I-SD) or by pasteurization (FVIII-P) respectively.The factor VIII content and the purity of both preparations were assessed in vitro, wheras in vivo we studied the recovery and the plasma half-life of both concentrates. The higher purity of FVIII-SD was confirmed. Factor VIII-P preparations contained more factor VIII than mentioned on the label. Both preparations gave good in vivo recoveries and half-lives. Patients who did not have antibodies to hepatitis B, hepatitis C or HI V at the initial screening, remained negative after six months treatment with the new concentrates. No patients developed neutralizing factor VIII antibodies. Furthermore patients appreciated the ease of administration of both preparations. In conclusion both FVIII concentrates are suited for the treatment of hamophelia A patients.
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