Temperature gradients in the range 2000°C/cm–3000°C/cm have been imposed across the interface of binary diffusion couples fabricated from fcc metals. The systems investigated were Au&sngbnd;Ni, Cu&sngbnd;Ni, &ggr;Fe&sngbnd;Ni, &ggr;Fe&sngbnd;Pd, and Ni&sngbnd;Pd. It was found that chemical diffusion in these systems was influenced in varying degrees by the temperature gradient. Suggestions are given for the manner in which the temperature gradient may affect the various contributions to chemical diffusion.