Chiral Resolution of Dipeptides by Ligand Exchange Chromatography on Chemically Bonded Chiral Phases
作者:
Gerald Gübitz,
Burkhard Vollmann,
Giuseppe Cannazza,
MartinG. Schmid,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 1996)
卷期:
Volume 19,
issue 17-18
页码: 2933-2942
ISSN:1082-6076
年代: 1996
DOI:10.1080/10826079608015118
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
This paper deals with studies on the optical resolution of glycyl-DL-amino acid dipeptides and diastereomeric dipeptides on three different chemically bonded chiral ligand exchange chromatography (LEC)-phases. The phases were prepared by binding L-proline or L-hydroxyproline to silica gel using different silanes as spacer. Using 10−5M copper(H) sulface as a mobile phase, eleven glycyl-dipeptides were resolved, nearly all of them with baseline separations. Several dipeptides containing two stereogenic centres were at least partially resolved into the four stereoisomers.
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