The production of pig tissue sulphadimidine reference material
作者:
S. R. H. Crooks,
W. J. Mccaughey,
C. T. Elliott,
J. D. Mcevoy,
S. A. Hewitt,
期刊:
Food Additives & Contaminants
(Taylor Available online 1996)
卷期:
Volume 13,
issue 2
页码: 211-219
ISSN:0265-203X
年代: 1996
DOI:10.1080/02652039609374399
出版商: Taylor & Francis Group
关键词: Sulphadimidine;reference material;pig tissue;high performance liquid chromatography
数据来源: Taylor
摘要:
The production of stable homogeneous reference materials containing the antimicrobial agent sulphadimidine in pig tissue is described. These were commissioned by the Community Bureau of Reference (BCR), established by the Commission of the European Communities, to promote improvements in analytical accuracy and to ensure uniformity of results determined by member states. Sulphadimidine‐containing tissue powders (400 vials each of muscle, liver and kidney) were prepared by orally dosing pigs with drug, producing lyophilized tissue powders and blending these with negative tissues from unmedicated animals to achieve target concentrations. Details of the production process, the stabilizing procedure developed and the analytical assessments of homogeneity and stability are given.
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