In vivo Hydrogen Peroxide Production in Rat Remnant Kidney
作者:
Christiane Van den Branden,
Joseph Vamecq,
Dierik Verbeelen,
Frank Roels,
期刊:
Kidney and Blood Pressure Research
(Karger Available online 1994)
卷期:
Volume 17,
issue 5
页码: 240-245
ISSN:1420-4096
年代: 1994
DOI:10.1159/000173828
出版商: S. Karger AG
关键词: Remnant kidney;Peroxisomes;Hydrogen peroxide production;Renal failure
数据来源: Karger
摘要:
In the rat remnant kidney hydrogen peroxide (H2O2) production is increased when compared to the normal kidney. The activities of the peroxisomal H2O2-producing oxidases, D-amino acid oxidase and acylcoenzyme A oxidase, and of the extraperoxisomal superoxide dismutase are decreased in renal homogenate. The peroxisomal L-α-hydroxyacid oxidase and L-lactate oxidase as well as the peroxisomal H2O2 scavenger catalase preserve their activity. The activity of the cytosolic scavenging system, glutathione peroxidase, is decreased by 40%. A starvation period of 48 h does not produce a measurable increase in H2O2 production in the normal nor in the remnant kidney. On visual inspection, peroxisomal morphology and distribution in the renal tubules are similar in the normal and remnant kidney tissue
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