NEUROLOGICAL MANIFESTATIONS OF LEPROSY
作者:
Thomas Swift,
Thomas Sabin,
期刊:
The Neurologist
(OVID Available online 1998)
卷期:
Volume 4,
issue 1
页码: 21-30
ISSN:1074-7931
年代: 1998
出版商: OVID
关键词: leprosy;neuritis;mycobacterium leprae;diagnosis;treatment;thalidomide
数据来源: OVID
摘要:
BACKGROUND- Leprosy affects millions worldwide and is surprisingly common in the United States. Leprous neuritis is the most common treatable neuropathy.REVIEW SUMMARY- Leprosy is the only disease in which bacteria regularly invade peripheral nerves, with a predilection for Schwann cells. Because of a low temperature optimum for mycobacterial growth, nerve damage occurs in cool areas, leading to a unique temperature-linked neuropathy. Recognition of the neurologic features permits early diagnosis and effective treatment with rifampin, dapsone, and clofazimine. Leprosy occurs in high-, medium-, and low-resistance forms. Superimposed reactions are immunologic phenomena that profoundly affect the degree of nerve damage. Stigma and rehabilitation are important aspects of leprosy.CONCLUSION- Leprosy produces a characteristic neuropathy easily recognizable by a neurologist.
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