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Elemental studies in rat lens during galactose cataract reversal

 

作者: UnakarN. J.,   BobrowskiW. F.,   TsuiJ. Y.,   BagchiM.,   HardingC. V.,  

 

期刊: Current Eye Research  (Taylor Available online 1993)
卷期: Volume 12, issue 7  

页码: 675-683

 

ISSN:0271-3683

 

年代: 1993

 

DOI:10.3109/02713689309001847

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

Alterations in elemental composition of the normal lens have been reported to accompany galactose cataract development in rats. In this report we present the changes in regional distribution of Na, K, CI, P, S and Ca during the reversal of galactose-induced cataracts. Elemental X-ray maps of lenses from young female Sprague Dawley rats fed 50% galactose for 20 days were examined at 0, 20, 40 and 90 days following the transfer of galactose fed rats to Purina Rat Chow diet. Reinstatement of normal elemental distribution accompanied the progression of lens transparency. By 90 days on the rat chow diet, K had increased and Na, CI and Ca had decreased so that a near normal lenticular distribution of these elements was established. The reinstatement of elemental distribution during cataract reversal followed a pattern similar to that observed for alterations during cataract development, initiating near the equatorial surface and expanding centrally. The correlation between the alterations in the distribution of the elements studied and our previously reported morphological investigation of lenses during galactose cataract reversal is discussed in this report.

 

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