Chemotherapy (CAP) for the Treatment of Advanced Ovarian Cancer and Second-Effort Surgery in the Second Look
作者:
M.B. Ojeda-González,
I. Alvárez-López,
M.C. Alonso-Muñoz,
J. Badía-Serra,
E. Delgado-Latre,
L. de Andrés-Basauri,
J.J. López-López,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 1
页码: 7-12
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226885
出版商: S. Karger AG
关键词: Laparotomy, second-look;Second-effort surgery;Doxorubicin;Adriamycin;Cisplatin;Advanced ovarian cancer;Ovarian cancer, FIGO stages III and IV;Chemotherapy;Cyclophosphamide
数据来源: Karger
摘要:
Seventy-two patients with advanced ovarian cancer received CAP chemotherapy followed by laparotomy and ‘second-effort’ surgery. The overall response to CAP therapy was 80%. A complete pathological response (CPR) was obtained in 16 patients and partial microscopic (PMiR) and macroscopic responses in 7 and 33 cases, respectively. The actuarial survival for the entire group was 36% at 50 months with a median survival of 34 months. No significant differences in survival between the CPR and PMiR groups were found. Radical second-effort surgery showed a somewhat beneficial effect. The tumor size before chemotherapy ( < 5 cm) and FIGO stage III had a significantly favorable effect on response rate and survival.
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