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Haemophilus influenzae type b polysaccharide‐protein conjugate vaccines in children

 

作者: Juhani Eskola,   Aino Takala,   Helena Kayhty,  

 

期刊: Current Opinion in Pediatrics  (OVID Available online 1993)
卷期: Volume 5, issue 1  

页码: 55-59

 

ISSN:1040-8703

 

年代: 1993

 

出版商: OVID

 

关键词: DPT—diphtheria-pertussis-tetanus;HbOC—Hib oligosaccharide-protein conjugate;Hib—Haemophilus influenzae type b;PRP-D—polysaccharide-diphtheria toxoid conjugate;PRP-OMP—polysaccharide-Ne/sseria meningitidis group B outer membra

 

数据来源: OVID

 

摘要:

Prevention of invasive infections caused by Haemophilus influenzae type b (Hib) bacteria has become possible with new vaccines. Covalent coupling to a protein carrier increases the immunogenicity of Hib capsular polysaccharide, and changes it to a T-cell dependent antigen. In clinical use, the conjugate vaccines are immunogenic in infancy, induce immunologic memory, and protect efficiently from invasive infections. They even seem to reduce oropharyngeal carriage of Hib bacteria. Wide-scale use of Hib conjugate vaccines has demonstrated their safety and low reactogenicity. Studies to combine them with other childhood vaccines are in progress. First signs of reduction of severe Hib infections can already be seen in countries where Hib conjugate vaccines are in wide use.

 

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