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Synthesis and conformational study of a cyclic hexapeptide analogue of somatostatin: cyclo(Phe‐D‐Trp‐Lys‐Thr‐o‐AMPA)

 

作者: P. VANDER ELST,   E. BERG,   H. PEPERMANS,   L. VANDER AUWERA,   R. ZEEUWS,   D. TOURWE,   G. BINST,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1987）
卷期: Volume 29, issue 3  

页码: 318-330

 

ISSN:0367-8377

 

年代: 1987

 

DOI:10.1111/j.1399-3011.1987.tb02259.x

 

出版商: Blackwell Publishing Ltd

 

关键词: conformation;cyclic peptide;somatostatin analogues;two‐dimensional n.m.r

 

数据来源: WILEY

 

摘要:

The active sequence Phe7‐D‐Trp8‐Lys9‐Thr10of somatostatin has been cyclized througho‐(aminomethyl)phenylacetic acid, a spacer molecule, designed to mimic a Gly‐Gly dipeptide containing acis‐constrained peptide bond. The resulting analogue shows no GH‐inhibition. A 2D n.m.r. study reveals conformations different from the proposed bio‐active one and still sensitive to the

 

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