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Valproic Acid: Update on Its Mechanisms of Action

 

作者: Daniel Johnston,  

 

期刊: Epilepsia  （WILEY Available online 1984）
卷期: Volume 25, issue 1  

页码: 1-4

 

ISSN:0013-9580

 

年代: 1984

 

DOI:10.1111/j.1528-1157.1984.tb05630.x

 

出版商: Blackwell Publishing Ltd

 

关键词: Valproic acid;Valproate;Anticonvulsant

 

数据来源: WILEY

 

摘要:

Valproic acid (VPA; 2‐propylpentanoic acid or dipropylacetic acid) was synthesized by Burton in 1882 and shown to have anticonvulsant properties by Meunier et al. in 1963. VPA was licensed for use as an anticonvulsant in the United States in 1978. It is used primarily for the treatment of generalized seizure

 

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