The Orphan Receptor SF‐1 Binds to the COUP‐Like Element in the Promoter of the Actively Transcribed Oxytocin Gene
作者:
Uwe Wehrenberg,
Stephanie Goedecke,
Richard Ivell,
Norbert Walther,
期刊:
Journal of Neuroendocrinology
(WILEY Available online 1994)
卷期:
Volume 6,
issue 1
页码: 1-4
ISSN:0953-8194
年代: 1994
DOI:10.1111/j.1365-2826.1994.tb00546.x
出版商: Blackwell Publishing Ltd
关键词: oxytocin;promoter;orphan receptor;SF‐1;corpus luteum
数据来源: WILEY
摘要:
The factors regulating oxytocin expression have not yet been characterized in detail. Although direct control by ligand‐dependent binding of nuclear hormone receptors to the oxytocin promoter has been suggested, the presence of these receptors in the tissues expressing oxytocin has not been shown consistently. We have analyzed nuclear proteins from preovulatory bovine granulosa cells and corpus luteum, tissues actively expressing the oxytocin gene, and describe here the characterization of a tissuespecific factor binding to the conserved element in the oxytocin promoter that has been implicated in the control of this gene. This factor is the bovine homologue of SF‐1, an orphan receptor expressed specifically in steroidogenic tissues. It is suggested that SF‐1 binds to the oxytocin promoterin vivoand is involved in control of oxytocin gene expression possibly by interaction with other fa
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