Antiviral Effects of 3′‐Fluorothymidine and 3′‐Azidothymidine in Cynomolgus Monkeys Infected with Simian Immunodeficiency Virus
作者:
Björn Lundgren,
Disa Böttiger,
Ewa Ljungdahl-Ståhle,
Erling Norrby,
Lars Ståhle,
Britta Wahren,
Bo Öberg,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1991)
卷期:
Volume 4,
issue 5
页码: 489-498
ISSN:0894-9255
年代: 1991
出版商: OVID
关键词: Simian immunodeficiency virus;cynomolgus monkey;Chemotherapy;3′-Fluorothy midine;3′-Azidothy midine
数据来源: OVID
摘要:
An acute infection with simian immunodeficiency virus (SIVSM) in cynomolgus monkeys was used to evaluate the antiviral effects of 3′-fluorothymidine (FLT) and 3′-azidothymidine [zidovudine (ZDV)]. Neither compound prevented the infection despite dosing prior to virus inoculation. FLT was about ten times more potent than ZDV in delaying the appearance of SIVSMantigen in the monkeys. The serum half-life of FLT was longer than that of ZDV and ZDV was bound to plasma proteins to about 60% while FLT was virtually unbound. It is proposed that the in vivo difference in potency between ZDV and FLT could, at least partly, be explained as the combined effects of a longer plasma half-life and a higher free concentration of FLT and possibly a higher intracellular concentration of the triphosphate of FLT.
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