Biomicroscopic and Histopathologic Observations After Corneal Laser Photocoagulation in a Rabbit Model of Corneal Neovascularization
作者:
Ramzi Hemady,
John Baer,
C Stephen Foster,
期刊:
Cornea
(OVID Available online 1993)
卷期:
Volume 12,
issue 3
页码: 185-190
ISSN:0277-3740
年代: 1993
出版商: OVID
关键词: Cornea;Laser photocoagulation;Neovascularization;Rabbits;Yellow light
数据来源: OVID
摘要:
Corneal neovascularization complicates many anterior segment diseases. Corneal laser photocoagulation using yellow light (577 nm) has been shown to reduce corneal neovascularization. No histopathologic studies of the effects of this treatment on the eye have been reported, however. Target (cornea) and nontarget (iris, lens, retina, and choroid) ocular tissue were studied 1, 24, and 48 h and 5 days after yellow dye corneal laser photocoagulation in a rabbit model of corneal neovascularization. Biomicroscopic examination of the corneas revealed intracorneal hemorrhage in five of 24 (21%) eyes of nonpigmented rabbits. Faint lenticular opacities were observed in two eyes of pigmented rabbits 24 h after laser treatment. Histopathologic examination revealed increased cellularity (neutrophils) (p < 0.005) in the cornea, increasing from 1 h after treatment, peaking 24 h later, and persisting past 5 days. Distortion of the corneal lamellae by red blood cells occurred in eyes in which intracorneal hemorrhage developed. These results indicate that corneal laser photocoagulation using yellow light is a relatively safe procedure for reducing corneal neovascularization.
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