Interferon inhibition of DNA synthesis and cell division
作者:
M. V. O'Shaughnessy,
S. H. S. Lee,
K. R. Rozee,
期刊:
Canadian Journal of Microbiology
(NRC Available online 1972)
卷期:
Volume 18,
issue 2
页码: 145-151
ISSN:0008-4166
年代: 1972
DOI:10.1139/m72-024
出版商: NRC Research Press
数据来源: NRC
摘要:
Using monodispersed cell suspensions, interferon preparations were shown to have both a lethal and a growth-depression effect in the same concentration range as that required for antiviral activity. In addition, synchronized cells treated with interferon respond by delaying their normal uptake of thymidine during S phase until after a period during which new protein is synthesized. Puromycin added during this period prevents both the synthesis of this protein and the subsequent synthesis of DNA.
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