Effect of High-Flux Hemodialysis on Quality of Life and Neuropsychological Function in Chronic Hemodialysis Patients
作者:
David N. Churchill,
Daniel R. Bird,
Wayne Taylor,
Mary Louise Beecroft,
Joanne Gorman,
Jean E. Wallace,
期刊:
American Journal of Nephrology
(Karger Available online 1992)
卷期:
Volume 12,
issue 6
页码: 412-418
ISSN:0250-8095
年代: 1992
DOI:10.1159/000168491
出版商: S. Karger AG
关键词: Hemodialysis;High-flux membranes;Neuropsychologic tests;Quality of life;Cross-over study
数据来源: Karger
摘要:
The objective was to evaluate the effect of high-flux hemodialysis on quality of life, intra- and interdialytic symptoms and neuropsychological function. The study was double-blind single cross-over with random allocation to order of treatment. The patients were stable adult hospital hemodialysis patients. Both the conventional and high-flux membranes were cellulose acetate, the dialy-sate was bicarbonate, and dialysate sodium was held constant. The high-flux membrane had an ultrafiltration rate of 15 ml/h/mm Hg transmembrane pressure, a B12 clearance of 88 ml/min and a β2-microglobulin clearance of 11.4 ml/min. The values for the conventional membrane were 3.5-5.0, 34-45 and negligible. Each treatment period was 4 months. Twenty-two patients completed both phases of the cross-over. The KT/V value was higher during high-flux than conventional treatment; 1.42 versus 1.27(p 0.01) and none were clinically significant. Symptoms between dialyses were less severe during high-flux than conventional treatment for 18/20 items. No single item had a statistically significant improvement but 3 had clinically important improvement. Among the 23 neuropsychological variables, none demonstrated statistically significant changes
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